Sertraline was developed by Pfizer Pharmaceuticals of the United States as an effective antidepressant with relatively few side effects. The brand name of this drug is Zoloft. This drug has the effect of increasing the amount of serotonin to a normal state, and serotonin is a neurotransmitter in the brain, and studies have reported that the less secreted it is, the more likely it is to commit suicide. Depressed patients with low levels of serotonin secretion are 4 to 6 times more likely to commit suicide than patients with normal levels of secretion.
In addition to depression, it is also effective in treating past recollections, nightmares, persistent avoidance, insomnia, and post-traumatic stress, so it received additional approval for an indication from the Food and Drug Administration (FDA) in 1999. However, this symptom was only effective for women who experienced war, sexual assault, or natural disaster, and clinical trials conducted on male veterans who experienced war were unsuccessful.
Sertraline has little to no cardiotoxicity, and side effects such as jaundice and hypertension, which were exposed by early antidepressants that appeared after the 1950s, were improved. Common side effects of sertraline include dizziness, fatigue, headache, insomnia, drowsiness, diarrhea, nausea, dry mouth, sexual dysfunction, tremors, increased sweating, chest pain, blurred vision, and ringing in the ears. Side effects of sertraline are dose-dependent and usually appear when taken over 100 mg.